Isyna1 myo-inositol 1-phosphate synthase A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Isyna1provided by MGI
Official Full Name: myo-inositol 1-phosphate synthase A1provided by MGI
Primary source: MGI:MGI:1919030
See related: Ensembl:ENSMUSG00000019139 AllianceGenome:MGI:1919030
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IPS 1; 1300017C10Rik
Summary: Predicted to enable inositol-3-phosphate synthase activity. Predicted to be involved in inositol biosynthetic process. Predicted to act upstream of or within phospholipid biosynthetic process. Predicted to be active in cytoplasm. Is expressed in early conceptus and retina. Orthologous to human ISYNA1 (inositol-3-phosphate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 323.5), testis adult (RPKM 232.1) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.15 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (71047131..71049940)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (70594481..70597290)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Isyna1 is highly expressed in two types of germ cells, pachytene spermatocytes and round spermatids
Title: Characterization of the expression and regulation of genes necessary for myo-inositol biosynthesis and transport in the seminiferous epithelium.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136244 (e-PCR)
- UniSTS:210238

UniSTS:498303 (e-PCR)
- UniSTS:498303

Isyna1 (e-PCR), detects polymorphism
- UniSTS:498303

RH126908 (e-PCR)
- UniSTS:208294

RH129421 (e-PCR)
- UniSTS:212728

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables inositol-3-phosphate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-3-phosphate synthase activity	ISO Inferred from Sequence Orthology more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inositol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inositol biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inositol-3-phosphate synthase 1

Names: MI-1-P synthase; MIP synthase

NP_076116.1

EC 5.5.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.